Indian Journal of Public Health Research & Development

Sunita Singh ¹, Vikrant Sharma ², Yogesh Rai ³, Vivek Singh ⁴

Affiliations
1 Department of Pharmacology, Saraswati Institute of Medical Sciences, Hapur, Ghaziabad, U.P., IN
2 Department of Ophthalmology, Saraswati Institute of Medical Sciences, Hapur, Ghaziabad, U.P., IN
3 Department of Biochemistry, Saraswati Institute of Medical Sciences, Hapur, Ghaziabad, U.P., IN
4 Department of Pharmacology of Saraswati Institute of Medical Sciences, Hapur, Ghaziabad, U.P., IN

Abstract

Objective: To study the prescribing pattern in cataract surgery patients in SIMS, for evaluation of their pharmacoepidemiology.

Material and methods: A retrospective study was conducted in the department of Pharmacology in collaboration with the department of Ophthalmology for a period of one year. Total 720 patients were analysed. Utilisation pattern of drugs like dosages form, route, frequency of administration and duration of therapy in preoperative, intraoperative and postoperative were audited. Drug prescription versus therapeutic indication was also evaluated.

Result: Different antibiotics mostly Fluoroquinolones, (like moxifloxacine (71.11%), gatifloxacine (16.66%), ofloxacin (4.16%) and, antiinflammatory drugs-bromofenac (54.27%), flurbiprofen (45.27%) and mydriatic-cucloplegic agents were prescribed.

Conclusion: The prescription was logical in respect of therapeutic indication. But in view of cost Moxifloxacin and Bromofenac could have been replaced by cheaper antibiotics and antiinflammtory drugs as Ofloxacin and Flurbiprofen.

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Vivek Singh ¹, Yogesh Kumar Rai ², Anil Kumar Kem ³

Affiliations
1 Department of Pharmacology, Saraswathi Institute of Medical Sciencies, Hapur, Ghaziabad, U.P., IN
2 Department of Biochemistry, Saraswathi Institute of Medical Sciencies, Hapur, Ghaziabad, U.P., IN
3 Department of Medicine, Saraswathi Institute of Medical Sciencies, Hapur, Ghaziabad, U.P., IN

Abstract

This study was undertaken to test the thyroid function with chronic renal failure. Forty patients of CRF and forty healthy who served as control were studied for their thyroid function status. The study observed low total T3 and total T4 values in clinically euthyroid CRF patients. However, finding of normal free T4 values (which is metabolically active fraction) and TSH would indicate functional euthyroid status. It can be presumed that free T4 values would fall if these patients develop hypothyroidism, and TSH values would rise simultaneously. Thus free T4 and TSH level combined can be used for diagnosis of hypothyroidism in presence of chronic renal failure. This study found that the plasma concentrations of thyroid hormones in patients with chronic renal failure both free T3 1.38±0.31 pmol/L and total T3 serum concentrations1.06±0.23 nmol/L were reduced as compare to control respectively. Similarly both serum freeT4 06.27±1.09 pmol/L and total T4 56.17±0.8.96 nmol/L were also reduced in chronic renal failure patients .There was slightly increase in serum TSH 6.21±0.73 mlU/L as compared to control 3.43±0.44 mlU/L. Thus it is suggested that thyroid hormones should be evaluated in chronic renal failure patients and thyroid hormone therapy should be given in these patients to maintain thyroid hormone level.

Keywords

Chronic Renal Failure (CRF), Creatinine Clearance, Goiter, Hypothyroidism, Thyroid Hormones (TH)

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